2013

European Journal of Organic Chemistry (2013) 228-255
35

2,1,3-Benzothiadiazole and Derivatives: Synthesis, Properties, Reactions and Applications in Light Technology of Small Molecules

 

B. A. D. Neto*, A. A. M. Lapis, E. N. da Silva Júnior, J. Dupont

European Journal of Medicinal Chemistry 62 (2013) 98-110
34

Cytotoxicity of lapachol, Beta-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells

 

S. N. Sunasee*, C. G. L. Veale, N. Shunmoogan-Gouden, O. Osoniyi, D. T. Hendricks, M. R. Caira, J. L. Mare, A. L. Edkins, A. V. Pinto, E. N. da Silva Júnior, M. T. D. Coleman

Journal of the Brazilian Chemical Society 24 (2013) 145-163
33

Potent Antileukemic action of Naphthoquinoidal compounds: Evidence for an Intrinsic Death Mechanism based on Oxidative Stress and Inhibition of DNA Repair

 

B. Coelho*, I. O. Cabral, F. A. Rodrigues, F. W. A. Barros, D. D. Rocha, H. I. F. Magalhães, D. J. Moura, J. Saffi, J. A. P. Henriques, T. S. C. Carvalho, M. O. Moraes, C. Pessoa, I. M. M. Melo, E. N. da Silva Júnior*

Featured in Front Cover

European Journal of Medicinal Chemistry 63 (2013) 523-530
32

Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: Synthesis of novel alfa- and nor-alfa-lapachone-based 1,2,3-triazoles by copper-catalyzed azide alkyne cycloaddition

 

T. T. Guimarães, M. C. F. R. Pinto, J. S. Lanza, M. N. Melo, R. Monte, I. M. M. Melo, E. B. T. Diogo, V. F. Ferreira, C. A. Camara, W. O. Valença, R. N. Oliveira, F. Frezard, E. N. da Silva Júnior*

Bioorganic & Medicinal Chemistry 21 (2013) 6337-6348
31

Synthesis and anti-Trypanosoma cruzi activity of Naphthoquinone-containing Triazoles: Electrochemical studies on the effects of the quinoidal moiety

 

E. B. T. Diogo, G. G. Dias, B. L. Rodrigues, T. T. Guimarães, W. O. Valença, C. A. Camara, R. N. de Oliveira, M. G. da Silva, V. F. Ferreira, Y. G. Paiva, M. O. F. Goulart, R. F. S. Menna-Barreto, S. L. de Castro, E. N. da Silva Júnior*

European Journal of Medicinal Chemistry 69 (2013) 678-700
30

Synthesis of quinoidal molecules: Strategies towards bioactive compounds with an emphasis on lapachones

 

S. L. de Castro, F. S. Emery, E. N. Da Silva Júnior*

Revista Virtual de Química 5 (2013) 1022-1047
29

Aspectos da Obra Científica de Antonio Ventura Pinto: Uma Vida Dedicada ao Estudo da Reatividade Química de Quinonas Naturais e Sintéticas

 

V. F. Ferreira*, K. C. G. Moura, M. C. F. R. Pinto, E. N. da Silva Júnior

2012

Journal of the Brazilian Chemical Societ 23 (2012) 770-781
28

Selective and Efficient Mitochondria Staining with Designed 2,1,3-Benzothiadiazole Derivatives as Live Cell Fluorescence Imaging Probes

 

B. A. D. Neto*, J. R. Correa, P. H. P. R. Carvalho, D. C. B. D. Santos, B. C. Guido, C. C. Gatto, H. C. B. Oliveira, M. Fasciotti, M. N. Eberlin, E. N. da Silva Júnior

Featured in Front Cover

Bioorganic & Medicinal Chemistry 20 (2012) 6482-6488
27

1,3-Azoles from ortho-naphthoquinones: Synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis

 

K. C. G. Moura, P. F. Carneiro, M. C. F. R. Pinto, J. A. Silva, V. R. S. Malta, C. A. Simone, G. G. Dias, G. A. M. Jardim, J. Cantos, T. S. Coelho, P. E. A. Silva*, E. N. da Silva Júnior*

European Journal of Medicinal Chemistry 52 (2012) 304-312
26

On the Search for Potential anti-Trypanosoma cruzi Drugs: Synthesis and Biological Evaluation of 2-Hydroxy-3-methylamino and 1,2,3-Triazolic Naphthoquinoidal Compounds obtained by Click Chemistry Reactions

 

E. N. da Silva Júnior*, I. M. M. Melo, E. B. T. Diogo, V. A. Costa, W. O. Valença, C. A. Camara, R. N. Oliveira, A. S. Araújo, F. S. Emery, M. R. Santos, C. A. de Simone, R. F. S. Menna-Barreto, S. L. Castro

Acta Farmaceutica Bonaerense 31 (2012) 507-513
25

Antimicrobial evaluation of quinones and heterocyclic compounds against Mycobacterium marinum, Mycobacterium kansasii and Mycobacterium abscessus

 

J. B. Cantos, T. S. Coelho, P. F. Carneiro, K. C. G. Moura, M. C. F. R. Pinto, E. N. da Silva Júnior, P. A. Silva*

Parasitology 139 (2012) 26-36
24

A novel triazolic naphthofuranquinone induces autophagy in reservosomes and impairment of mitosis in Trypanosoma cruzi

 

M. C. Fernandes, E. N. da Silva Júnior, A. V. Pinto, S. L. Castro, R. F. S. Menna-Barreto*

Toxicology in Vitro 26 (2012) 585-594
23

Growth inhibitory effects of 3'-Nitro-3-Phenylamino nor-beta-lapachone against HL-60: a redox dependent mechanism

 

A. J. Araujo, A. A. Souza, E. N. da Silva Júnior, J. D. B. Marinho Filho, M. A. B. F. de Moura, D. D. Rocha, M. C. Vasconcellos, C. O. Costa, C. Pessoa, C. M. O. Moraes, V. F. Ferreira, F. C. de Abreu, A. V. Pinto, R. C. Montenegro, L. V. Costa-Lotufo*, M. O. F. Goulart*

2011

European Journal of Medicinal Chemistry 46 (2011) 399-410
22

Synthesis and evaluation of quinonoid compounds against tumor cell lines

 

E. N. Da Silva Júnior*, B. C. Cavalcanti, T. T. Guimarães, M. C. F. R. Pinto, I. O. Cabral, C. Pessoa, L. V. Costa-Lotufo, M. O. Moraes, C. K. Z. Andrade, M. R. Santos, C. A. Simone, M. O. F. Goulart, A. V. Pinto

Tetrahedron Letters 52 (2011) 2415-2418
21

Synthesis and characterisation of a new polycyclic phenazine from 1,4-naphthoquinone

 

M. J. Silva, M. C. F. R. Pinto, C. A. Simone, J. G. Soares, J. R. M. Reys, J. D. Souza Filho, W. T. A. Harrison, C. E. M. Carvalho, M. O. F. Goulart, E. N. da Silva Júnior*, A. V. Pinto

Molecules 16 (2011) 10314-10323
20

Antimony(V) and Bismuth(V) Complexes of Lapachol: Synthesis, Crystal Structure and Cytotoxic Activity

 

L. G. de Oliveira, M. M. Silva, F. C. S. de Paula, E. C. Pereira-Maia, C. L. Donnici, C. A. de Simone, F. Frézard, E. N. da Silva Júnior, C. Demicheli

European Journal of Medicinal Chemistry 46 (2011) 4521-4529
19

Quinonoid and phenazine compounds: Synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis

 

P. F. Carneiro, M. C. F. R. Pinto, T. S. Coelho, B. C. Cavalcanti, C. Pessoa, C. A. Simone, I. K. C. Nunes, N. M. de Oliveira, R. G. Almeida, A. V. Pinto, K. C. G. Moura, P. A. Silva*, E. N. da Silva Júnior*

Current Microbiology 62 (2011) 684-689
18

Identification of Nor-beta-Lapachone Derivatives as Potential Antibacterial Compounds against Enterococcus faecalis Clinical Strain

A. L. Lourenço, P. A. Abreu, B. Leal, E. N. da Silva Júnior, A. V. Pinto, M. C. F. R. Pinto, A. M. T. Souza, J. S. Novais, M. B. Paiva, L. M. Cabral, C. R. Rodrigues, V. F. Ferreira, H. C. Castro*

Chemical Research in Toxicology 24 (2011) 1560-1574
17

Preclinical Genotoxicology of Nor-Beta-lapachone in Human Cultured Lymphocytes and Chinese Hamster Lung Fibroblasts

 

B. C. Cavalcanti*, F. W. A. Barros, I. O. Cabral, J. R. O. Ferreira, H. I. F. Magalhaes, H. V. Nobre Júnior, E. N. da Silva Júnior, F. C. de Abreu, C. O. Costa, M. O. F. Goulart, M. O. Moraes, C. Pessoa

Laboratory of Synthetic and Heterocyclic Chemistry,

Institute of Exact Sciences, Department of Chemistry,
Federal University of Minas Gerais, Belo Horizonte, Brazil

Adress : Av. Pres. Antônio Carlos, 6627 - Pampulha,

Belo Horizonte - MG

E-mail: eufranio@ufmg.br

Phone Number: +55 31 34095696