Chemical Science 7 (2016) 3780-3784

Overcoming naphthoquinone deactivation: rhodium-catalyzed C-5 selective C-H iodination as a gateway to functionalized derivatives


G. A. M. Jardim, E. N. da Silva Júnior* and J. F. Bower*

Highlighted ChemInform, 2016, 47, DOI: 10.1002/chin.201641099.

Highlighted in Themed collection SBQ-RSC: Celebrating UK-Brazil collaborations.

Organic Letters 18 (2016) 4454-4457

Rh-Catalyzed Reactions of 1,4-Benzoquinones with Electrophiles: C-H Iodination, Bromination, and Phenylselenation


G. A. M. Jardim, J. F. Bower* and E. N. da Silva Júnior*

Chemical Communications 52 (2016) 13281-13284

Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone


T. B. Gontijo, R. P. de Freitas, G. F. de Lima, L. C. D. de Rezende, L. F. Pedrosa, T. L. Silva, M. O. F. Goulart, B. C. Cavalcanti, C. Pessoa, M. P. Bruno, J. R. Corrêa, F. S. Emery* and E. N. da Silva Júnior*

European Journal of Medicinal Chemistry 122 (2016) 1-16

Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights


E. H. G. da Cruz, M. A. Silvers, G. A. M. Jardim, J. M. Resende, B. C. Cavalcanti, I. S. Bomfim, C. Pessoa, C. A. de Simone, G. A. Botteselle, A. L. Braga, D. K. Nair, I. N. N. Namboothiri, D. A. Boothman and E. N. da Silva Júnior*

Organic & Biomolecular Chemistry 14 (2016) 913-6931

Catalytic asymmetric reactions and synthesis of quinones


B. Hosamani, M. F. Ribeiro, E. N. da Silva Júnior* and I. N. N. Namboothiri*

Medicinal Chemistry Communication 7 (2016) 1555-1563

Molecular hybridization as a powerful tool towards multitarget quinoidal systems: synthesis, trypanocidal and antitumor activities of naphthoquinone-based 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles


S. B. B. B. Bahia, W. J. Reis, G. A. M. Jardim, F. T. Souto, C. A. de Simone, C. Gatto, R. F. S. Menna-Barreto, S. L. de Castro, B. C. Cavalcanti, C. Pessoa, M. H. Araujo and E. N. da Silva Júnior*

Featured in Front Cover.

Highlighted in Themed collection New Talent: Americas.

RSC Advances 6 (2016) 76056-76063

Fluorescent Oxazoles from Quinones for Bioimaging Applications


B. A. D. Neto, G. G. Dias, P. Pinho, H. A. Duarte, J. M. Resende, A. Rosa, J. R. Corrêa* and E. N. da Silva Júnior*

Molecules 21 (2016) 873

Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells


M. P. Costa, A. C. S. Feitosa, F. C. O. E. Oliveira, B. C. Cavalcanti, E. N. da Silva Júnior, G. G. Dias, F. A. M. Sales, B. L. Sousa, I. L. Barroso-Neto, C. Pessoa, E. W. S. Caetano*, S. Fiore, R. Fischer, L. O. Ladeira and V. N. Freire

Tetrahedron Letters 57 (2016) 5017-5021

Synthesis, 11B- and 19F NMR spectroscopy, and optical and electrochemical properties of novel 9-aryl-3-(aryl/heteroaryl)-1,1-difluoro-7-(trifluoromethyl)-1H-[1,3,5,2]oxadiazaborinino[3,4-a][1,8]naphthyridin-11-ium-1-uide complexes


H. G. Bonacorso, T. P. Calheiro, B. A. Iglesias, I. R. C. Berni, E. N. da Silva Júnior, J. B. T. Rocha, N. Zanatta and M. A. P. Martins


Chemical Communications 51 (2015) 9141-9144

Selective Endocytic Trafficking in Live Cells with Fluorescent Naphthoxazoles and their Boron Complexes


G. G. Dias, B. L. Rodrigues, J. M. Resende, H. D. R. Calado, C. A. de Simone, V. H. C. Silva, B. A. D. Neto, M. O. F. Goulart, F. R. Ferreira, A. S. Meira, C. Pessoa, J. R. Correa* and E. N. da Silva Júnior*

The Journal of Organic Chemistry 80 (2015) 2120-2127

Catalytic chalcogenylation under greener conditions: A solvent-free sulfur- and seleno-functionalization of olefins via I2/DMSO oxidant system


A. A. Vieira, J. B. Azeredo, M. Godoi, C. Santi, E. N. da Silva Júnior and A. L. Braga*

European Journal of Medicinal Chemistry 101 (2015) 254-265

Hybrid Compounds with Two Redox Centres: Modular Synthesis of Chalcogen-Containing Lapachones and Studies on their Antitumor Activity


A. A. Vieira, I. R. Brandao, W. O. Valença, C. A. Simone, B. C. Cavalcanti, C. Pessoa, T. R. Carneiro, A. L. Braga and E. N. da Silva Júnior*

Organic & Biomolecular Chemistry 13 (2015) 1996-2000

Synthesis of imidazoles via cascade reaction of nitroallylic acetates with amidines and studies on their trypanocidal activity


T. Kumar, D. Verma, R. F. S. Menna-Barreto, W. O. Valença, E. N. da Silva Júnior* and I. N. N. Namboothiri*

Organic & Biomolecular Chemistry 13 (2015) 9862-9871

Imidazoles from nitroallylic acetates and α-bromonitroalkenes with amidines: synthesis and trypanocidal activity studies


E. Golpi, T. Kumar, R. F. S. Menna-Barreto, W. O. Valença, E. N. da Silva Júnior* and I. N. N. Nambothiri*

Medicinal Chemistry Communications 6 (2015) 120-130

Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines


G. A. M. Jardim, T. T. Guimarães, M. C. F. R. Pinto, B. C. Cavalcanti, K. M. de Farias, C. Pessoa, C. C. Gatto, D. K. Nair, I. N. N. Namboothiri* and E. N. da Silva Júnior*

European Journal of Organic Chemistry 2015 (2015) 703-709

Synthesis of a Phenazine-Based 1,2,3-Triazole from Naturally Occurring Naphthoquinone Designed as a Probe for Cd Ions


G. A. M. Jardim, H. D. R. Calado, L. A. Cury and E. N. da Silva Júnior*

RSC Advances 5 (2015) 78047-78060

On the Investigation of Hybrid Quinones: Synthesis, Electrochemical Studies and Evaluation of Trypanocidal Activity


G. A. M. Jardim, W. J. Reis, M. F. Ribeiro, F. M. Ottoni, R. J. Alves, T. L. Silva, M. O. F. Goulart, A. L. Braga, R. F. S. Menna-Barreto, K. Salomao, S. L. Castro and E. N. da Silva Júnior*

Journal of the Brazilian Chemical Society 26 (2015) 1013-1027

On the Search for Potential Antimycobacterial Drugs: Synthesis of Naphthoquinoidal, Phenazinic and 1,2,3-Triazolic Compounds and Evaluation Against Mycobacterium tuberculosis


G. A. M. Jardim, E. H. G. Cruz, W. O. Valença, J. M. Resende, B. L. Rodrigues, D. F. Ramos, R. N. Oliveira, P. A. Silva and E. N. da Silva Júnior*


Chemical Communications 50 (2014) 6973-6976

Chiral squaramide catalyzed asymmetric synthesis of pyranones and pyranonaphthoquinones via cascade reactions of 1,3-dicarbonyls with Morita-Baylis-Hillman acetates of nitroalkenes


D. K. Nair, R. F. S. Menna-Barreto, E. N. da Silva Júnior*, S. M. Mobim and I. N. N. Namboothiri*

Featured in Front Cover.

The Journal of Organic Chemistry 79 (2014) 5201-5208

Nature of Electrogenerated Intermediates in Nitro-Substituted Nor-β-lapachones: The Structure of Radical Species during Successive Electron Transfer in Multiredox Centers

G. Armendáriz-Vidales, L. S. Henández-Muñoz, F. J. González, A. A. Souza, F. C. de Abreu, G. A. M. Jardim, E. N. da Silva Júnior, M. O. F. Goulart* and C. Frontana*

Bioorganic & Medicinal Chemistry 22 (2014) 1608-1619

1,2,3-Triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: Potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones


E. H. G. Cruz, C. M. B. Hussene, G. G. Dias, E. B. T. Diogo, I. M. M. Melo, B. L. Rodrigues, M. G. Silva, W. O. Valença, C. A. Camara, R. N. Oliveira, Y. G. Paiva, M. O. F. Goulart, B. C. Cavalcanti, C. Pessoa and E. N. da Silva Júnior*

New Journal of Chemistry 38 (2014) 2569-2580

Design, synthesis and application of fluorescent 2,1,3-benzothiadiazole-triazole-linked biologically active lapachone derivatives


E. H. G. Cruz, P. H. P. R. Carvalho, J. R. Correa, D. A. C. Silva, E. B. T. Diogo, J. D. Souza Filho, B. C. Cavalcanti, C. Pessoa, H. C. B. Oliveira, B. C. Guido, D. A. Silva Filho, B. A. D. Neto* and E. N. da Silva Júnior*

Plos One 9 (2014) e93698

Antifungal Activity of Naphthoquinoidal Compounds In Vitro against Fluconazole-Resistant Strains of Different Candida Species: A Special Emphasis on Mechanisms of Action on Candida tropicalis

J. B. A. Neto, C. R. Silva, M. A. S. Neta, R. S. Campos, J. T. Sibeira, D. M. Gaspar, H. I. F. Magalhaes, M. O. Moraes, M. D. P. Lobo, T. B. Grangeiro, T. S. Carvalho, E. B. T. Diogo, E. N. da Silva Júnior, F. A. Rodrigues, B. C. Cavalcanti and H. V. Nobre Júnior

Memórias do Instituto Oswaldo Cruz 109 (2014) 546-552

Blood shizonticide activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice with malaria

N. B. Souza, I. M. Andrade, P. F. Carneiro, G. A. M. Jardim, I.M. M. Melo and E. N. da Silva Júnior*, A. U. Krettli*

Journal of the Brazilian Chemical Society 25 (2014) 1780-1798

Anti-Trypanosoma cruzi Compounds: Our Contribution for the Evaluation and Insights on the Mode of Action of Naphthoquinones and Derivatives

E. N. da Silva Júnior, G. A. M. Jardim, R. F. S. Menna-Barreto and S. L. Castro*

RSC Advances: 4 (2014) 54282-54299.

What do we know about multicomponent reactions? Mechanisms and trends for the Biginelli, Hantzsch, Mannich, Passerini and Ugi MCRs

H. G. O. Alvim, E. N. da Silva Júnior and B. A. D. Neto*

Laboratory of Synthetic and Heterocyclic Chemistry,

Institute of Exact Sciences, Department of Chemistry,
Federal University of Minas Gerais, Belo Horizonte, Brazil

Address: Av. Pres. Antônio Carlos, 6627 - Pampulha,

Belo Horizonte - MG

E-mail: eufranio@ufmg.br

Phone Number: +55 31 34095696