The Journal of Organic Chemistry 86 (2021) 264-278

Rhodium(III)-Catalyzed C–H/N–H Alkyne Annulation of nonsymmetric 2-aryl (benz)imidazole derivatives:

Photophysical and Mechanistic Insights


G. G. Dias, E. R. S. Paz, J. Y. Kadooca, A. A. Sabino, L. A. Cury, K. Torikai, C. A. de Simone, F. Fantuzzi and E. N. da Silva Júnior*

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Chemistry A European Journal (2021) accepted article

Decoding directing groups and their pivotal role in C–H activation

K. Murali, L. A. Machado, R. L. Carvalho, L. F. Pedrosa, R. Mukherjee, E. N. da Silva Júnior* and D. Maiti*

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Bioorganic & Medicinal Chemistry 40 (2021) 116164

Ruthenium(II)- and Palladium(II)-Catalyzed Position-Divergent C–H
Oxygenations of Arylated Quinones: Identification of Hydroxylated Quinonoid
Compounds with Potent Trypanocidal Activity

T. B. Gontijo, R. L. Carvalho, L. Dantas-Pereira, R. F. S. Menna-Barreto, T. Rogge, L. Ackermann* and E. N. da Silva Júnior*

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Journal of the Brazilian Chemical Society 32 (2021) 917

A Catalysis Guide Focusing on C–H Activation Processes


R. L. Carvalho, G. G. Dias, C. L. M. Pereira, P. Ghosh, D. Maiti* and E. N. da Silva Júnior*

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Featured in Front Cover

Organic & Biomolecular Chemistry 19 (2021) 525-547

Removal and modification of directing groups used in metal-catalyzed C–H functionalization: The magical step of conversion into ‘conventional’ functional groups


R. L. Carvalho, R. G. Almeida, M. Karunanidhi, L. A. Machado, L. F. Pedrosa, P. Dolui, D. Maiti* and E. N. da Silva Júnior*

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Beilstein Journal of Organic Chemistry 17 (2021) 762-770 

Synthesis of β-triazolylenones via metal-free desulfonylative alkylation of N-tosyl-1,2,3-triazoles


S. Pati, R. G. Almeida, E. N. da Silva Júnior* and I. N. N. Namboothiri*

Journal of Drug Deliv. Sci. Technology 62 (2021) 102348

Liposomes containing 3-arylamino-nor-β-lapachone derivative: development, characterization, and in vitro evaluation of the cytotoxic activity


L. V. Rebouças, F. C. E. Oliveira, D. P. Pinheiro, A. C. A. Oliveira, R. G. Almeida, E. N. da Silva Júnior, M. S. Rizzo, M. P. Costa*, G. Zocolo, F. O. S. Ribeiro, D. A. da Silva and C. Pessoa

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The Chemical Record (2021) in press

The Different Facets of Metal-Catalyzed C–H Functionalization Involving Quinone Compounds


J. M. Wood, R. L. Carvalho and E. N. da Silva Júnior*

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This article also appears in: 18th Brazilian Meeting on Organic Synthesis and Hot Topic: C-H Activation

Bioorganic Chemistry 109 (2021) 104662

A new class of Cathepsin K inhibitors based on 2-amino-1,3,4-oxadiazole

T. B. Gontijo, P. S. Lima, M. Y. Icimoto, E. C. de Alvarenga, A. K. Carmona, A. A. de Castro, T. C. Ramalho, E. N. da Silva Júnior and R. P. de Freitas*

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CrystEngComm 23 (2021) 1885-1897

Ferromagnetic coupling in a dicopper(II) oxamate complex bridged by carboxylate groups

T. T. da Cunha, C. O. C. da Silveira, V. M. M. Barbosa, W. X. C. Oliveira, E. N. da Silva Júnior, F. F. Ferreira, E. F. Pedroso, C. L. M. Pereira*

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Featured in Front Cover

Chemical Biology & Drug Design (2021) accepted article

Benzo[a]phenazine derivatives: promising scaffolds to combat resistant Mycobacterium tuberculosis

P. C. B. Halicki, E. N. da Silva Junior, G. A. M. Jardim, R. G. de Almeida, J. R. M. Vicenti, B. L. Gonçalves, P. E. Almeida da Silva and D. F. Ramos*

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Current Pharmaceutical Design 27 (2021) 1807-1824

Naphthoquinones and derivatives for chemotherapy: perspectives and limitations of their anti-trypanosomatids activities


L. Dantas-Pereira, E. F. Cunha-Junior, V. V. Andrade-Neto, J. F. Bower, G. A. M. Jardim, E. N. da Silva Júnior, E. C. Torres-Santos and R. F. S. Menna-Barreto*


Organic Letters 22 (2020) 265-269

Rh-catalyzed [2+2+2] cycloadditions with benzoquinones: de novo access to naphthoquinones for lignan and type II polyketide synthesis


J. M. Wood, E. N. da Silva Júnior* and J. F. Bower*


Part of a Special Issue: Celebrating Chemistry in Latin America

Chemistry A European Journal 26 (2020) 10981-10986

Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds


E. N. da Silva Júnior,* R. L. de Carvalho, R. G. Almeida, L. G. Rosa, F. Fantuzzi, T. Rogge, P. M. S. Costa, C. Pessoa, C. Jacob and L. Ackermann*

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Part of a Special Issue for the 8th EuChemS Chemistry Congress consisting of contributions from selected speakers and conveners.

To view the complete issue, visit Issue 48.

The Journal of Organic Chemistry 85 (2020) 8825-8843

Synthesis of Densely Substituted Sulfonylfurans and Dihydrofurans via Cascade Reactions of α-Functionalized Nitroalkenes with β-Ketosulfones


V. Mane, S. Sivanandan, R. Santana, A. Beatriz, E. N. da Silva Júnior* and I. N. N. Namboothiri*

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Featured in Front Cover

European Journal of Organic Chemitry (2020) 4474-4486

Electrochemical selenation/cyclization of quinones: A rapid, green and efficient access to functionalized trypanocidal and
antitumor compounds


A. Kharma, C. Jacob,* I. A. O. Bozzi, G. A. M. Jardim, A. L. Braga, K. Salomão, C. C. Gatto, M. F. S. Silva, C. Pessoa, M. Stangier, L. Ackermann* and E. N. da Silva Júnior*

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Featured in Front Cover

Bioorganic & Medicinal Chemistry 28 (2020) 115565

Strategies towards potent trypanocidal drugs: application of Rh-catalyzed [2+2+2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi


J. M. Wood, N. S. Satam, R. G. Almeida, V. S. Cristani, D. P. Lima, L. D. Pereira, K. Salomão, R. F. S. Menna-Barreto, I. N. N. Namboothiri*, J. F. Bower* and E. N. da Silva Júnior*

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RSC Medicinal Chemistry 11 (2020) 1145-1160

Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: Redox and biological implications


R. G. Almeida, W. O. Valença, L. G. Rosa, C. A. de Simone, S. L. de Castro, J. M. C. Barbosa, D. P. Pinheiro, C. R. K. Paier, G. G.
C. de Carvalho, C. Pessoa, M. O. F. Goulart, A. Kharma 
and E. N. da Silva Júnior*

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Featured in Front Cover

Future Microbiology 15 (2020) 1543-1554

Antifungal activity of β-lapachone against Candida spp. resistant to azoles and its aspects upon biofilm formation

C. R. da Silva,* R. de S Campos, J. B. A. Neto, L. S. Sampaio, F. B. S. A. do Nascimento, L. G. A. V. Sá, T. M. Cândido, H. I. F. Magalhães, E. H. G. da Cruz, E. N. da Silva Júnior, M. O. de Moraes, B. C. Cavalcanti, J. Silva, E. S Marinho and H. V. N. Júnior* 


New Journal of Chemistry 43 (2019) 13751-13763

Copper complexes and carbon nanotube-copper ferrite-catalyzed benzenoid A-ring selenation of quinones: An efficient method for the synthesis of trypanocidal agents


G. A. M. Jardim, I. A. O. Bozzi, W. X. C. Oliveira, C. Mesquita-Rodrigues, R. F. S. Menna-Barreto, R. A. Kumar, E. Gravel, E. Doris,* A. L. Braga and E. N. da Silva Júnior*

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Catalysis Science & Technology 9 (2019) 2742-2748 

Carbon nanotube-ruthenium hybrid towards mild oxidation of sulfides to sulfones: Efficient synthesis of diverse sulfonyl compounds


R. G. Almeida, R. L. de Carvalho, M. P. Nunes, R. S. Gomes, L. F. Pedrosa, C. A. de Simone, E. Gopi, V. Geertsen, E. Gravel, E. Doris* and E. N. da Silva Júnior*

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Featured in Cover.

Highlighted in Themed collection 2019 Catalysis Science & Technology HOT Articles.

European Journal of Medicinal Chemistry 179 (2019) 863-915

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones


E. N. da Silva Júnior,* G. A. M. Jardim, C. Jacob, U. Dhawa, L. Ackermann and S. L. de Castro

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Bioorganic & Medicinal Chemistry 27 (2019) 4143-4150

Design of hybrid molecules as antimycobacterial compounds: Synthesis of isoniazid-naphthoquinone derivatives and their activity against susceptible and
resistant strains of Mycobacterium tuberculosis

W. J. Reis, I. A. O. Bozzi, M. F. Ribeiro, P. C. B. Halicki, L. A. Ferreira, P. E. A. da Silva, D. F. Ramos,* C. A. de Simone and E. N. da Silva Júnior*

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Bioorganic & Medicinal Chemistry 27 (2019) 3938-3946

Natural product-inspired profluorophores for imaging NQO1 activity in tumour


Z. M. Cheng, W. O. Valença, G. G. Dias, J. Scott, N. D. Barth, F. Moliner, G. B. P. Souza, R. J. Mellanby, M. Vendrell* and E. N. da Silva Júnior*

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Featured in the special issue 'Chemical Immunology'

Tetrahedron 75 (2019) 3697-3712 

Beyond Copper-Catalyzed Azide-Alkyne 1,3-dipolar Cycloaddition: Synthesis and
mechanism insights


R. S. Gomes, G. A. M. Jardim, R. L. de Carvalho, M. H. Araujo and E. N. da Silva Júnior*

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European Journal of Organic Chemistry (2019) 2344-2353 

Ruthenium(II)-Catalyzed C–H Alkenylation of Quinones: Diversity-Oriented Strategy for Trypanocidal Compounds


G. G. Dias, T. A. do Nascimento, A. K. A. de Almeida, A. C. S. Bombaça, R. F. S. Menna-Barreto, C. Jacob, S. Warratz, E. N. da Silva Júnior* and L. Ackermann*

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Free Radical Biology & Medicine 130 (2019) 408-418

Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles.


A. C. S. Bombaça, P. G. Viana, A. C. C. Santos, T. L. Silva, A. B. M. Rodrigues, A. C. R. Guimarães, M. O. F. Goulart, E. N. da Silva Júnior and R. F. S. Menna-Barreto* 

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Physical Chemistry Chemical Physics 21 (2019) 3814-3821

Dynamics of aggregated states resolved by gated
fluorescence in films of room temperature phosphorescent emitters.


P. L. dos Santos, O. J. Silveira, R. Huang, G. A. M. Jardim, M. J. S. Matos, E. N. da Silva Júnior, A. P. Monkman, F. B. Dias and L. A. Cury*

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Journal of Fluorine Chemistry 220 (2019) 9-15

On the synthesis, optical and computational studies of novel BODIPY-based phosphoramidate fluorescent dyes.


L. A. Machado, M. C. de Souza, C. M. da Silva, J. Yoneda, L. C. D. de Rezende, F. S. Emery, C. A. de Simone, E. N. da Silva Júnior* and L. F. Pedrosa*

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Physical Chemistry Chemical Physics 21 (2019) 21966-21971

Multi-conformational monomer and dimer steady-states in domains of few molecules: the consequences on the phosphorescence emission bands.

G. H. R. Soares, G. A. M. Jardim, E. N. da Silva Júnior and L. A. Cury*

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Chemical Society Reviews 47 (2018) 12-27

Quinone-based fluorophores for imaging biological processes


G. G. Dias, A. King, F. de Moliner, M. Vendrell* and E. N. da Silva Júnior*

Featured in Front Cover

Highlighted in Themed collection 2018 Emerging Investigators.

Highlighted in Themed collection SBQ-RSC: Celebrating UK-Brazil collaborations.

Chemical Science 9 (2018) 6899-6903

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor


T. Rodrigues*, M. Werner, J. Roth, E. H. G. da Cruz, M. C. Marques, P. Akkapeddi, S. A. Lobo, A. Koeberle, F. Corzana, E. N. da Silva Júnior, O. Werz and G. J. L. Bernardes*

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Chemical Communications 54 (2018) 7398-7411

Weakly-coordinating N-oxide and carbonyl groups for metal catalyzed C–H activation: The case of A-ring functionalization


E. N. da Silva Júnior*, G. A. M. Jardim, R. S. Gomes, Y.-F. Liang and L. Ackermann*

Featured in Inside Front Cover.

Chemistry A European Journal 24 (2018) 15227-15235

Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon Nanotube-Rhodium Nanohybrid for Naphthols Oxidation: An Efficient Route towards Trypanocidal Quinones


R. L. de Carvalho, G. A. M. Jardim, A. C. C. Santos, M. H. Araujo, W. X. C. Oliveira, A. C. S. Bombaça, R. F. S. Menna-Barreto, E. Gopi, E, Gravel, E. Doris* and E. N. da Silva Júnior*

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Featured in Front Cover and Selected as HOT PAPER.

Chemical Communications 54 (2018) 12840-12843

Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents


G. G. Dias, T. Rogge, R. Kuniyil, C. Jacob, R. F. S. Menna-Barreto, E. N. da Silva Júnior* and L. Ackermann*

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European Journal of Medicinal Chemistry 151 (2018) 686-704

Quinonoid Compounds via Reactions of Lawsone and 2-Aminonaphthoquinone with α-Bromonitroalkenes and Nitroallylic Acetates: Structural Diversity by C-ring Modification and Cytotoxic Evaluation against Cancer Cells


T. V. Baiju, R. G. Almeida, S. T. Sivanandan, C. A. de Simone, L. M. Brito, B. C. Cavalcanti, C. Pessoa, I. N. N. Namboothiri* and E. N. da Silva Júnior*

Organic & Biomolecular Chemistry 16 (2018) 1686-1691

Direct sequential C-H iodination/organoyl-thiolation for benzenoid A-ring modification of quinonoid deactivated systems: A new protocol for potent trypanocidal quinones


G. A. M. Jardim, W. X. C. Oliveira, R. P. de Freitas, R. F. S. Menna-Barreto, T. L. Silva, M. O. F. Goulart and E. N. da Silva Júnior*

Molecules 23 (2018) 83

Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions


G. A. M. Jardim, E. H. G. da Cruz, W. O. Valença, D. J. B. Lima, B. C. Cavalcanti, C. Pessoa, J. Rafique, A. L. Braga, C. Jacob* and E. N. da Silva Júnior*

Chemical Physics Letters 695 (2018) 176-182

Vibronic singlet and triplet steady-state interplay emissions in phenazine-based 1,2,3-triazole films


B. B. A. Costa, P. D. C. Souza, R. N. Gontijo, G. A. M. Jardim, R. L. Moreira, E. N. da Silva Júnior and L. A. Cury*

Journal of Fluorine Chemistry 205 (2018) 8-14

Multinuclear NMR spectroscopy, photophysical, electrochemical and DNA-binding properties of fluorinated 1,8-naphthyridine-based boron heterocycles


H. G. Bonacorso*, T. P. Calheiro, B. A. Iglesias, Carolina H. da Silveira, E. N. da Silva Júnior, A. Ketzer, F. Bublitz, N. Zanatta and M. A. P. Martins

Current Topics in Medicinal Chemistry 18 (2018) 1-7

A UBI 31-38 Peptide-coumarin Conjugate: Photophysical Features, Imaging Tracking and Synergism with Amphotericin B Against Cryptococcus


S. M. Z. M. D. Ferreira, H. C. Carneiro, R. B. Alves, A. C. S. Batista, E. N. da Silva Júnior, G. G. Dias, J. M. Resende, D. A. Santos, D. L. Oliveira, M. L. Rodrigues and R. P. Freitas*

Frontiers in Chemistry 6 (2018) 339

Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplet

F. de Moliner, A. King, G. G. Dias, G. F. de Lima, C A. de Simone, E N. da Silva Júnior* and M. Vendrell*

Microbial Pathogenesis 117 (2018) 32-42

Action mechanism of naphthofuranquinones against fluconazole-resistant Candida tropicalis strains evidenced by proteomic analysis: The role of increased endogenous ROS

J. B. A. Neto, C. R. da Silva, R. S. Campos, F. B. S. A. do Nascimento, L. S. Sampaio, A. R. da Silva, M. A. A. Josino, M. O. de Moraes, M. D. P. Lobo, F. B. M. B. Moreno, A. C. O. M. Moreira, R. A. Moreira, T. B. Grangeiro, E. N. da Silva Júnior, H. I. F. Magalhães, D. D. Rocha, B. C. Cavalcanti and H. V. Nobre Júnior*


Physical Chemistry Chemical Physics 19 (2017) 3473-3479

Indirect consequences of exciplex states on the phosphorescence lifetime of phenazine-based 1,2,3-triazole luminescent probe


B. B. A. Costa, G. A. M. Jardim, P. L. Santos, H. D. R. Calado, A. P. Monkman, F. B. Dias, E. N. da Silva Júnior and L. A. Cury*

Featured in Front Cover.

Highlighted in Themed collection SBQ-RSC: Celebrating UK-Brazil collaborations.

European Journal of Medicinal Chemistry 136 (2017) 406-419

Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: Significant Anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones


G. A. M. Jardim, T. L. Silva, M. O. F. Goulart, C. A. de Simone, J. M. C. Barbosa, K. Salomão, S. L. de Castro, J. F. Bower and E. N. da Silva Júnior*

ChemistrySelect 2 (2017) 4301-4308

Synthesis of Quinone-Based N-Sulfonyl-1,2,3-triazoles: Chemical Reactivity of Rh(II) Azavinyl Carbenes and Antitumor Activity


W. O. Valença, T. V. Baiju, F. G. Brito, M. H. Araujo, C. Pessoa, B. C. Cavalcanti, C. A. de Simone, C. Jacob, I. N. N. Namboothiri* and E. N. da Silva Júnior*

New Journal of Chemistry 41 (2017) 3723-3731

Cyclometalated ruthenium complexes from naturally occurring quinones: Studies on their photophysical features, computational details and trypanocidal activity


C. M. de Souza, R. C. Silva, P. O. Fernandes, J. D. de Souza Filho, H. A. Duarte, M. H. Araujo, C. A. de Simone, S. L. de Castro, R. F. S. Menna-Barreto, C. P. Demicheli and E. N. da Silva Júnior*

Featured in Front Cover.

European Journal of Organic Chemistry (2017) 3763-3773

Redox Center Modification of Lapachones Toward the Syntheses of Nitrogenated Heterocycles as Selective Fluorescent Mitochondrial Imaging Probes


F. S. dos Santos, G. G. Dias, R. P. de Freitas, Lucas S. Santos, G. F. de Lima, H. A. Duarte, C. A. de Simone, L. M. S. L. Rezende, M. J. X. Vianna, J. R. Correa, B. A. D. Neto and E. N. da Silva Júnior*

Featured in Front Cover.

Bioorganic & Medicinal Chemistry Letters 27 (2017) 4446-4456

On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells


T. B. Gontijo, R. P. de Freitas, F. S. Emery, L. F. Pedrosa, J. B. Vieira Neto, B. C. Cavalcanti, C. Pessoa, A. King, F. de Moliner, M. Vendrell* and E. N. da Silva Júnior*

Medicinal Chemical Communications 8 (2017) 1993-2002

Encapsulation of nor-β-lapachone into poly(D,L)-lactide-co-glycolide (PLGA) microcapsules: full characterization, computational details and cytotoxic activity against human cancer cell lines


M. P. Costa, A. C. S. Feitosa, F. C. E. Oliveira, B. C. Cavalcanti, G. G. Dias, E. W. S. Caetano, F. A. M. Sales, V. N. Freire, S. Di Fiore, R. Fischer, L. O. Ladeira, E. N. da Silva Júnior* and C. Pessoa*