Chemical Communications 58 (2022) 3101-3121

Looking deep into C–H functionalization: the synthesis and application of cyclopentadienyl and related metal catalyst


G. A. M. Jardim, R. L. de Carvalho, M. P. Nunes, L. A. Machado, L. D. Almeida, K. A. Bahou, John F. Bower* and E. N. da Silva Júnior*

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European Journal of Organic Chemistry 28 (2022) e202200590

Ruthenium(II)-Catalyzed C–H/N–H Alkyne Annulation of Nonsymmetric Imidazoles: Mechanistic Insights by Computation and Photophysical Properties


L. A. Machado, E. R. S. Paz, M. H. Araujo, L. D. Almeida, I. A. O. Bozzi, G. G. Dias, C. L. M. Pereira, L. F. Pedrosa, F. Fantuzzi, F. T. Martins, L. A. Cury and E. N. da Silva Júnior*

Journal of Chemical Information and Modeling (2022) in press

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2


A. J. O'Donoghue,* E. N. da Silva Júnior,* R. S. Ferreira* and co-workers

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Chemosensors 10 (2022) 19

Rational Design and Synthesis of Large Stokes Shift 2,6-Sulphur-Disubstituted BODIPYs for Cell Imaging

A. E. Reese, C. Lochenie, A. Geddis, L. A. Machado, M. C. de Souza, F. F. C. Marques, C. A. de Simone, M. M. Gouvêa, L. F. Pedrosa, E. N. da Silva Júnior* and Marc Vendrell*

Physical Chemistry Chemical Physics 24 (2022) 1183-1190

Raman spectra-based structural classificatory analysis of quinoidal and derivative molecular systems

A. P. Pena, R. G. Almeida, J. Campos, H. F. dos Santos, E. N. da Silva Júnior and A. Jorio*

Bioorganic Chemistry 124 (2022) 105754

Design, Synthesis and in vivo Evaluation of 1,4-dioxo-2-butenyl Aryl Amine Derivatives as a Promising Anti-inflammatory Drug Prototype

I. O. M. F. da Silveira, I. S. B. Moslaves, J. A. I. Muller, R. J. Oliveira, C. R. W. Hortelan, T. T. Okuyama, J. Fernandes, B. Badenoch, L. J. de Campos, L. D. Almeida, J. Mohammad, A. C. F. Martins, A. Beatriz, E. N. da Silva Júnior, M. C. Toffoli-Kadri* and R. S. Gomes*

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Journal of Fluorescence 32 (2022) 1299-1308

Multi-conformational luminescence and phosphorescence of few phenazine 1,2,3-triazole molecules


P. B. Pinto, K. C. T. da Cruz, E. N. da Silva Júnior and L. A. Cury*


The Chemical Record 21 (2021) 2602-2603

Special issue: The Brazilian Meeting on Organic Synthesis

A. Fatima and E. N. da Silva Júnior*

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Beilstein Journal of Organic Chemistry 17 (2021) 1849-1938

On the application of 3d metals for C–H activation toward bioactive compounds:
The key step for the synthesis of silver bullets

R. L. Carvalho, A. S. de Miranda, M. P. Nunes, R. S. Gomes, G. A. M. Jardim* and E. N. da Silva Júnior*

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Chemistry A European Journal 27 (2021) 12453-12508

Decoding directing groups and their pivotal role in C–H activation

K. Murali, L. A. Machado, R. L. Carvalho, L. F. Pedrosa, R. Mukherjee, E. N. da Silva Júnior* and D. Maiti*

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This article also appears in: Chemistry Europe Reviews Hot Topic: C-H Activation

Journal of the Brazilian Chemical Society 32 (2021) 917

A Catalysis Guide Focusing on C–H Activation Processes


R. L. Carvalho, G. G. Dias, C. L. M. Pereira, P. Ghosh, D. Maiti* and E. N. da Silva Júnior*

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Featured in Front Cover

Organic & Biomolecular Chemistry 19 (2021) 525-547

Removal and modification of directing groups used in metal-catalyzed C–H functionalization: The magical step of conversion into ‘conventional’ functional groups


R. L. Carvalho, R. G. Almeida, M. Karunanidhi, L. A. Machado, L. F. Pedrosa, P. Dolui, D. Maiti* and E. N. da Silva Júnior*

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Advanced Synthesis & Catalysis 363 (2021) 4994-5027

Transition-Metal-Catalyzed Selective Alkynylation of C-H Bonds


A. S. Sarala, S. Bhowmick, R. L. de Carvalho, S. A. Al-Thabaiti, M. Mokhtar, E. N. da Silva Júnior* and D. Maiti*

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The Journal of Organic Chemistry 86 (2021) 264-278

Rhodium(III)-Catalyzed C–H/N–H Alkyne Annulation of nonsymmetric 2-aryl (benz)imidazole derivatives:

Photophysical and Mechanistic Insights


G. G. Dias, E. R. S. Paz, J. Y. Kadooca, A. A. Sabino, L. A. Cury, K. Torikai, C. A. de Simone, F. Fantuzzi and E. N. da Silva Júnior*

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RSC Medicinal Chemistry 12 (2021) 1709-1721

It takes two to Tango: Synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity

D. J. B. Lima, R. G. Almeida, G. A. M. Jardim, B. P. A. Barbosa, A. C. C. Santos, W. O. Valença, M. R. Scheide, C. C. Gatto, G. G. C. de Carvalho, P. M. S. Costa, C. Pessoa, C. L. M. Pereira, C. Jacob, A. L. Braga* and E. N. da Silva Júnior*

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Journal of Drug Deliv. Sci. Technology 62 (2021) 102348

Liposomes containing 3-arylamino-nor-β-lapachone derivative: development, characterization, and in vitro evaluation of the cytotoxic activity


L. V. Rebouças, F. C. E. Oliveira, D. P. Pinheiro, A. C. A. Oliveira, R. G. Almeida, E. N. da Silva Júnior, M. S. Rizzo, M. P. Costa*, G. Zocolo, F. O. S. Ribeiro, D. A. da Silva and C. Pessoa

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The Chemical Record 21 (2021) 2604-2637

The Different Facets of Metal-Catalyzed C–H Functionalization Involving Quinone Compounds


J. M. Wood, R. L. Carvalho and E. N. da Silva Júnior*

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This article also appears in: 18th Brazilian Meeting on Organic Synthesis and Hot Topic: C-H Activation

Bioorganic & Medicinal Chemistry 40 (2021) 116164

Ruthenium(II)- and Palladium(II)-Catalyzed Position-Divergent C–H
Oxygenations of Arylated Quinones: Identification of Hydroxylated Quinonoid
Compounds with Potent Trypanocidal Activity

T. B. Gontijo, R. L. Carvalho, L. Dantas-Pereira, R. F. S. Menna-Barreto, T. Rogge, L. Ackermann* and E. N. da Silva Júnior*

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The Chemical Record 21 (2021) 2702-2738

Imidazoles and Oxazoles from Lapachones and Phenanthrene-9,10-dione: A Journey through their Synthesis, Biological Studies, and Optical Applications


G. G. Dias, E. R. S. Paz, M. P. Nunes, R. L. Carvalho, M. O. Rodrigues, F. S. Rodembusch* and E. N. da Silva Júnior*

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Beilstein Journal of Organic Chemistry 17 (2021) 762-770 

Synthesis of β-triazolylenones via metal-free desulfonylative alkylation of N-tosyl-1,2,3-triazoles


S. Pati, R. G. Almeida, E. N. da Silva Júnior* and I. N. N. Namboothiri*

Chemical Biology & Drug Design 98 (2021) 352-362

Benzo[a]phenazine derivatives: promising scaffolds to combat resistant Mycobacterium tuberculosis

P. C. B. Halicki, E. N. da Silva Júnior, G. A. M. Jardim, R. G. de Almeida, J. R. M. Vicenti, B. L. Gonçalves, P. E. Almeida da Silva and D. F. Ramos*

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Bioorganic Chemistry 109 (2021) 104662

A new class of Cathepsin K inhibitors based on 2-amino-1,3,4-oxadiazole

T. B. Gontijo, P. S. Lima, M. Y. Icimoto, E. C. de Alvarenga, A. K. Carmona, A. A. de Castro, T. C. Ramalho, E. N. da Silva Júnior and R. P. de Freitas*

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CrystEngComm 23 (2021) 1885-1897

Ferromagnetic coupling in a dicopper(II) oxamate complex bridged by carboxylate groups

T. T. da Cunha, C. O. C. da Silveira, V. M. M. Barbosa, W. X. C. Oliveira, E. N. da Silva Júnior, F. F. Ferreira, E. F. Pedroso, C. L. M. Pereira*

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Featured in Front Cover

Dalton Transactions 50 (2021) 12430-12434

Unexpected formation of a dodecanuclear {CoII6CuII6} nanowheel under ambient conditions: magneto-structural correlations


W. D. do Pim, I. F. Silva, E. N. da Silva Júnior, H. O. Stumpf, W. X. C. Oliveira, E. F. Pedroso, C. B. Pinheiro, Y. Journaux, F. Fantuzzi, I. Krummenacher, H. Braunschweig, B. Engels, J. Cano, M. Julve and C. L. M. Pereira*

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Current Pharmaceutical Design 27 (2021) 1807-1824

Naphthoquinones and derivatives for chemotherapy: perspectives and limitations of their anti-trypanosomatids activities


L. Dantas-Pereira, E. F. Cunha-Júnior, V. V. Andrade-Neto, J. F. Bower, G. A. M. Jardim, E. N. da Silva Júnior, E. C. Torres-Santos and R. F. S. Menna-Barreto*


Organic Letters 22 (2020) 265-269

Rh-catalyzed [2+2+2] cycloadditions with benzoquinones: de novo access to naphthoquinones for lignan and type II polyketide synthesis


J. M. Wood, E. N. da Silva Júnior* and J. F. Bower*


Part of a Special Issue: Celebrating Chemistry in Latin America

Chemistry A European Journal 26 (2020) 10981-10986

Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds


E. N. da Silva Júnior,* R. L. de Carvalho, R. G. Almeida, L. G. Rosa, F. Fantuzzi, T. Rogge, P. M. S. Costa, C. Pessoa, C. Jacob and L. Ackermann*

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Part of a Special Issue for the 8th EuChemS Chemistry Congress consisting of contributions from selected speakers and conveners.

To view the complete issue, visit Issue 48.

The Journal of Organic Chemistry 85 (2020) 8825-8843

Synthesis of Densely Substituted Sulfonylfurans and Dihydrofurans via Cascade Reactions of α-Functionalized Nitroalkenes with β-Ketosulfones


V. Mane, S. Sivanandan, R. Santana, A. Beatriz, E. N. da Silva Júnior* and I. N. N. Namboothiri*

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Featured in Front Cover

European Journal of Organic Chemitry (2020) 4474-4486

Electrochemical selenation/cyclization of quinones: A rapid, green and efficient access to functionalized trypanocidal and
antitumor compounds


A. Kharma, C. Jacob,* I. A. O. Bozzi, G. A. M. Jardim, A. L. Braga, K. Salomão, C. C. Gatto, M. F. S. Silva, C. Pessoa, M. Stangier, L. Ackermann* and E. N. da Silva Júnior*

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Featured in Front Cover

Bioorganic & Medicinal Chemistry 28 (2020) 115565

Strategies towards potent trypanocidal drugs: application of Rh-catalyzed [2+2+2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi


J. M. Wood, N. S. Satam, R. G. Almeida, V. S. Cristani, D. P. Lima, L. D. Pereira, K. Salomão, R. F. S. Menna-Barreto, I. N. N. Namboothiri*, J. F. Bower* and E. N. da Silva Júnior*

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RSC Medicinal Chemistry 11 (2020) 1145-1160

Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: Redox and biological implications


R. G. Almeida, W. O. Valença, L. G. Rosa, C. A. de Simone, S. L. de Castro, J. M. C. Barbosa, D. P. Pinheiro, C. R. K. Paier, G. G.
C. de Carvalho, C. Pessoa, M. O. F. Goulart, A. Kharma 
and E. N. da Silva Júnior*

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Featured in Front Cover

Future Microbiology 15 (2020) 1543-1554

Antifungal activity of β-lapachone against Candida spp. resistant to azoles and its aspects upon biofilm formation

C. R. da Silva,* R. de S Campos, J. B. A. Neto, L. S. Sampaio, F. B. S. A. do Nascimento, L. G. A. V. Sá, T. M. Cândido, H. I. F. Magalhães, E. H. G. da Cruz, E. N. da Silva Júnior, M. O. de Moraes, B. C. Cavalcanti, J. Silva, E. S Marinho and H. V. N. Júnior* 


New Journal of Chemistry 43 (2019) 13751-13763

Copper complexes and carbon nanotube-copper ferrite-catalyzed benzenoid A-ring selenation of quinones: An efficient method for the synthesis of trypanocidal agents


G. A. M. Jardim, I. A. O. Bozzi, W. X. C. Oliveira, C. Mesquita-Rodrigues, R. F. S. Menna-Barreto, R. A. Kumar, E. Gravel, E. Doris,* A. L. Braga and E. N. da Silva Júnior*

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Catalysis Science & Technology 9 (2019) 2742-2748 

Carbon nanotube-ruthenium hybrid towards mild oxidation of sulfides to sulfones: Efficient synthesis of diverse sulfonyl compounds


R. G. Almeida, R. L. de Carvalho, M. P. Nunes, R. S. Gomes, L. F. Pedrosa, C. A. de Simone, E. Gopi, V. Geertsen, E. Gravel, E. Doris* and E. N. da Silva Júnior*

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Featured in Cover.

Highlighted in Themed collection 2019 Catalysis Science & Technology HOT Articles.

European Journal of Medicinal Chemistry 179 (2019) 863-915

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones


E. N. da Silva Júnior,* G. A. M. Jardim, C. Jacob, U. Dhawa, L. Ackermann and S. L. de Castro

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Bioorganic & Medicinal Chemistry 27 (2019) 4143-4150

Design of hybrid molecules as antimycobacterial compounds: Synthesis of isoniazid-naphthoquinone derivatives and their activity against susceptible and
resistant strains of Mycobacterium tuberculosis

W. J. Reis, I. A. O. Bozzi, M. F. Ribeiro, P. C. B. Halicki, L. A. Ferreira, P. E. A. da Silva, D. F. Ramos,* C. A. de Simone and E. N. da Silva Júnior*