da Silva Júnior Group
Organic and Medicinal chemistry
2016
Highlighted ChemInform, 2016, 47, DOI: 10.1002/chin.201641099.
Highlighted in Themed collection SBQ-RSC: Celebrating UK-Brazil collaborations.
Rh-Catalyzed Reactions of 1,4-Benzoquinones with Electrophiles: C-H Iodination, Bromination, and Phenylselenation
G. A. M. Jardim, J. F. Bower* and E. N. da Silva Júnior*
Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone
T. B. Gontijo, R. P. de Freitas, G. F. de Lima, L. C. D. de Rezende, L. F. Pedrosa, T. L. Silva, M. O. F. Goulart, B. C. Cavalcanti, C. Pessoa, M. P. Bruno, J. R. Corrêa, F. S. Emery* and E. N. da Silva Júnior*
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights
E. H. G. da Cruz, M. A. Silvers, G. A. M. Jardim, J. M. Resende, B. C. Cavalcanti, I. S. Bomfim, C. Pessoa, C. A. de Simone, G. A. Botteselle, A. L. Braga, D. K. Nair, I. N. N. Namboothiri, D. A. Boothman and E. N. da Silva Júnior*
Catalytic asymmetric reactions and synthesis of quinones
B. Hosamani, M. F. Ribeiro, E. N. da Silva Júnior* and I. N. N. Namboothiri*
Molecular hybridization as a powerful tool towards multitarget quinoidal systems: synthesis, trypanocidal and antitumor activities of naphthoquinone-based 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles
S. B. B. B. Bahia, W. J. Reis, G. A. M. Jardim, F. T. Souto, C. A. de Simone, C. Gatto, R. F. S. Menna-Barreto, S. L. de Castro, B. C. Cavalcanti, C. Pessoa, M. H. Araujo and E. N. da Silva Júnior*
Featured in Front Cover.
Highlighted in Themed collection New Talent: Americas.
Fluorescent Oxazoles from Quinones for Bioimaging Applications
B. A. D. Neto, G. G. Dias, P. Pinho, H. A. Duarte, J. M. Resende, A. Rosa, J. R. Corrêa* and E. N. da Silva Júnior*
Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells
M. P. Costa, A. C. S. Feitosa, F. C. O. E. Oliveira, B. C. Cavalcanti, E. N. da Silva Júnior, G. G. Dias, F. A. M. Sales, B. L. Sousa, I. L. Barroso-Neto, C. Pessoa, E. W. S. Caetano*, S. Fiore, R. Fischer, L. O. Ladeira and V. N. Freire
Synthesis, 11B- and 19F NMR spectroscopy, and optical and electrochemical properties of novel 9-aryl-3-(aryl/heteroaryl)-1,1-difluoro-7-(trifluoromethyl)-1H-[1,3,5,2]oxadiazaborinino[3,4-a][1,8]naphthyridin-11-ium-1-uide complexes
H. G. Bonacorso, T. P. Calheiro, B. A. Iglesias, I. R. C. Berni, E. N. da Silva Júnior, J. B. T. Rocha, N. Zanatta and M. A. P. Martins
2015
Selective Endocytic Trafficking in Live Cells with Fluorescent Naphthoxazoles and their Boron Complexes
G. G. Dias, B. L. Rodrigues, J. M. Resende, H. D. R. Calado, C. A. de Simone, V. H. C. Silva, B. A. D. Neto, M. O. F. Goulart, F. R. Ferreira, A. S. Meira, C. Pessoa, J. R. Correa* and E. N. da Silva Júnior*
Catalytic chalcogenylation under greener conditions: A solvent-free sulfur- and seleno-functionalization of olefins via I2/DMSO oxidant system
A. A. Vieira, J. B. Azeredo, M. Godoi, C. Santi, E. N. da Silva Júnior and A. L. Braga*
Hybrid Compounds with Two Redox Centres: Modular Synthesis of Chalcogen-Containing Lapachones and Studies on their Antitumor Activity
A. A. Vieira, I. R. Brandao, W. O. Valença, C. A. Simone, B. C. Cavalcanti, C. Pessoa, T. R. Carneiro, A. L. Braga and E. N. da Silva Júnior*
Synthesis of imidazoles via cascade reaction of nitroallylic acetates with amidines and studies on their trypanocidal activity
T. Kumar, D. Verma, R. F. S. Menna-Barreto, W. O. Valença, E. N. da Silva Júnior* and I. N. N. Namboothiri*
Imidazoles from nitroallylic acetates and α-bromonitroalkenes with amidines: synthesis and trypanocidal activity studies
E. Golpi, T. Kumar, R. F. S. Menna-Barreto, W. O. Valença, E. N. da Silva Júnior* and I. N. N. Nambothiri*
Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines
G. A. M. Jardim, T. T. Guimarães, M. C. F. R. Pinto, B. C. Cavalcanti, K. M. de Farias, C. Pessoa, C. C. Gatto, D. K. Nair, I. N. N. Namboothiri* and E. N. da Silva Júnior*
Synthesis of a Phenazine-Based 1,2,3-Triazole from Naturally Occurring Naphthoquinone Designed as a Probe for Cd Ions
G. A. M. Jardim, H. D. R. Calado, L. A. Cury and E. N. da Silva Júnior*
On the Investigation of Hybrid Quinones: Synthesis, Electrochemical Studies and Evaluation of Trypanocidal Activity
G. A. M. Jardim, W. J. Reis, M. F. Ribeiro, F. M. Ottoni, R. J. Alves, T. L. Silva, M. O. F. Goulart, A. L. Braga, R. F. S. Menna-Barreto, K. Salomao, S. L. Castro and E. N. da Silva Júnior*
On the Search for Potential Antimycobacterial Drugs: Synthesis of Naphthoquinoidal, Phenazinic and 1,2,3-Triazolic Compounds and Evaluation Against Mycobacterium tuberculosis
G. A. M. Jardim, E. H. G. Cruz, W. O. Valença, J. M. Resende, B. L. Rodrigues, D. F. Ramos, R. N. Oliveira, P. A. Silva and E. N. da Silva Júnior*
2014
Chiral squaramide catalyzed asymmetric synthesis of pyranones and pyranonaphthoquinones via cascade reactions of 1,3-dicarbonyls with Morita-Baylis-Hillman acetates of nitroalkenes
D. K. Nair, R. F. S. Menna-Barreto, E. N. da Silva Júnior*, S. M. Mobim and I. N. N. Namboothiri*
Featured in Front Cover.
Nature of Electrogenerated Intermediates in Nitro-Substituted Nor-β-lapachones: The Structure of Radical Species during Successive Electron Transfer in Multiredox Centers
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G. Armendáriz-Vidales, L. S. Henández-Muñoz, F. J. González, A. A. Souza, F. C. de Abreu, G. A. M. Jardim, E. N. da Silva Júnior, M. O. F. Goulart* and C. Frontana*
1,2,3-Triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: Potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones
E. H. G. Cruz, C. M. B. Hussene, G. G. Dias, E. B. T. Diogo, I. M. M. Melo, B. L. Rodrigues, M. G. Silva, W. O. Valença, C. A. Camara, R. N. Oliveira, Y. G. Paiva, M. O. F. Goulart, B. C. Cavalcanti, C. Pessoa and E. N. da Silva Júnior*
Design, synthesis and application of fluorescent 2,1,3-benzothiadiazole-triazole-linked biologically active lapachone derivatives
E. H. G. Cruz, P. H. P. R. Carvalho, J. R. Correa, D. A. C. Silva, E. B. T. Diogo, J. D. Souza Filho, B. C. Cavalcanti, C. Pessoa, H. C. B. Oliveira, B. C. Guido, D. A. Silva Filho, B. A. D. Neto* and E. N. da Silva Júnior*
Antifungal Activity of Naphthoquinoidal Compounds In Vitro against Fluconazole-Resistant Strains of Different Candida Species: A Special Emphasis on Mechanisms of Action on Candida tropicalis
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J. B. A. Neto, C. R. Silva, M. A. S. Neta, R. S. Campos, J. T. Sibeira, D. M. Gaspar, H. I. F. Magalhaes, M. O. Moraes, M. D. P. Lobo, T. B. Grangeiro, T. S. Carvalho, E. B. T. Diogo, E. N. da Silva Júnior, F. A. Rodrigues, B. C. Cavalcanti and H. V. Nobre Júnior
Blood shizonticide activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice with malaria
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N. B. Souza, I. M. Andrade, P. F. Carneiro, G. A. M. Jardim, I.M. M. Melo and E. N. da Silva Júnior*, A. U. Krettli*
Anti-Trypanosoma cruzi Compounds: Our Contribution for the Evaluation and Insights on the Mode of Action of Naphthoquinones and Derivatives
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E. N. da Silva Júnior, G. A. M. Jardim, R. F. S. Menna-Barreto and S. L. Castro*
What do we know about multicomponent reactions? Mechanisms and trends for the Biginelli, Hantzsch, Mannich, Passerini and Ugi MCRs
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H. G. O. Alvim, E. N. da Silva Júnior and B. A. D. Neto*
From the themed collection: How does it work? – a collection on mechanistic studies