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2024

The Synthesis and Reactivity of Naphthoquinonynes

 

R. L. de Carvalho, J. M. Wood, R. G. Almeida, N. G. Berry, E. N. da Silva Júnior* and J. F. Bower*

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Bypassing Ammonia: From N2 to Nitrogen Heterocycles without N1 Intermediates or Transition Metals

 

M. Weber, T. Kupfer, M. Arrowsmith, R. D. Dewhurst, M. Rang, B. Ritschel, S. Titlbach, M. Ernst, M. Oliveira Rodrigues, E. N. da Silva Júnior and H. Braunschweig*

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Chemistry A European Journal (2024) e202303883
142

Electrochemical Diselenation of BODIPY Fluorophores for Bioimaging Applications and Sensitization of singlet oxygen

 

Í. A. O. Bozzi, L. A. Machado, E. B. T. Diogo, F. G. Delolo, L. O. F. Barros, G. A. P. Graça, M. H. Araujo, F. T. Martins, L. F. Pedrosa, L. C. da Luz, E. S. Moraes, F. S. Rodembusch, J. S. F. Guimarães, A. G. Oliveira, S. H. Röttger, D. B. Werz, C. P. Souza, F. Fantuzzi, J. Han, T. B. Marder, H. Braunschweig* and E. N. da Silva Júnior*

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This article also appears in: Hot Topic: Fluorine Chemistry Society Volumes: Germany

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Chemistry A European Journal (2024) e202400244
141

Cover Profile: Electrochemical Diselenation of BODIPY Fluorophores for Bioimaging Applications and Sensitization of singlet oxygen

 

Í. A. O. Bozzi, L. A. Machado, E. B. T. Diogo, F. G. Delolo, L. O. F. Barros, G. A. P. Graça, M. H. Araujo, F. T. Martins, L. F. Pedrosa, L. C. da Luz, E. S. Moraes, F. S. Rodembusch, J. S. F. Guimarães, A. G. Oliveira, S. H. Röttger, D. B. Werz, C. P. Souza, F. Fantuzzi, J. Han, T. B. Marder, H. Braunschweig* and E. N. da Silva Júnior*

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Journal of Luminescence 265 (2024) 120221
140

Waveguided phosphorescence through a gain medium by an in-plane pulsed laser stripe

 

W. J. E. de Paula, G. A. M. Sáfar, E. N. da Silva Júnior and L. A. Cury*

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Current Organic Synthesis (2024) in press
139

BODIPYs as Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets: Photophysical and Computational Studies

 

L. A. Machado, C. L. M. Pereira, A. C. G. de Souza, E. A. Ferreira, F. F. C. Marques, E. Orestes, M. H. Araujo, K. L. R. Paiva, M. S. Mesquita, S. N. Báo,* L. F. Pedrosa, M. J. Nasim, C. Jacob* and E. N. da Silva Júnior*

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2023

Chemical Society Reviews 52 (2023) 6359-6378
138

The Crucial Role of Silver(I)-Salts as Additives on C–H Activation Reactions: Overall Analysis of their Versatility and Applicability

 

R. L. de Carvalho, E. B. T. Diogo, S. L. Homölle, S. Dana, E. N. da Silva Júnior* and L. Ackermann*

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This article is part of the themed collections: 2023 Pioneering Investigators and Celebrating the scientific accomplishments of RSC Fellows

Bioorganic & Medicinal Chemistry 94 (2023) 117479
137

Selenoneine-inspired selenohydantoins with glutathione peroxidase-like activity

 

R. Alhasan, G. M. Martins, P. P. de Castro, R. S. Z. Saleem, A. Zaiter,  I. Fries-Raeth, A. Kleinclauss, C. Perrin-Sarrado, P. Chaimbault, E. N. da Silva Júnior*, C. Gaucher* and C. Jacob

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European Journal of Organic Chemistry (2023) e202300506
136

Electrochemical Sulphenylation/Cyclization of Quinones: A Rapid, Green and Efficient Access to Cytotoxic Compounds

 

E. B. T. Diogo, F. G. Delolo, G. A. P. Graça, E. R. S. Paz, I. A. O. Bozzi, R. Diniz, J. P. Passos, T. Matencio, L. K. Soares, D. Alves, P. M. S. Costa, C. Pessoa, C. L. M. Pereira, L. Ackermann* and E. N. da Silva Júnior*

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Chemical Communications 59 (2023) 2763-2766
135

Solvent-free hydroboration of alkenes and alkynes catalyzed by rhodium-ruthenium nanoparticles on carbon nanotubes

 

M. P. Nunes, D. V. Jawale, F. G. Delolo, M. H. Araujo, E. Gravel,* E. Doris* and E. N. da Silva Júnior*

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Featured in Synfacts 2023, 19, 0601.

Molecules 28 (2023) 2222
134

It Takes Two to Tango, Part II: Synthesis of A-ring Functionalised Quinones Containing Two Redox-Active Centres with Antitumour Activities

 

J. C. de Oliveira, R. L. de Carvalho, H. G. S. Sampaio, J. Honorato, J. A. Ellena, F. T. Martins, J. V. M. Pereira, P. M. S. Costa, C. Pessoa, R. S. Ferreira, M. H. Araújo, C. Jacob and E. N. da Silva Júnior*

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Chemical Research in Toxicology 36 (2023) 66-82
133

ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics

 

R. J. Oliveira,* I. O. M. F. Silveira, S. C. Neves, B. Mitsuyasu, A. C. Martins, C. Berno, J. Mohammad, H. Raj, F. H. S. de Araujo, C. R. Hortelan, L. Machado, E. N. da Silva Júnior, M. L. B. Vilela, V. A. Nascimento, A. Beatriz and R. S. Gomes*

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Organic & Biomolecular Chemistry 21 (2023) 4606-4619
132

Sensitive Hydrazine Detection and Quantification with a Fluorescent Benzothiadiazole Sensor: Selective Lipid Droplets and In Vivo Imaging

 

C. O. Santos, S. T. A. Passos, J. E. P. Sorto, D. F. S. Machado, J. R. Correia, E. N. da Silva Júnior, M. O. Rodrigues and B. A. D. Neto*

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RSC Advances 13 (2023) 11121-11129
131

First report of trans-A2B-corrole derived from a lapachone derivative: Photophysical, TD-DFT and Photobiological assays

 

B. M. Rodrigues, C. C. Diniz, V. N. da Rocha, M. H. Köhler, G. P. Brandão, L. A. Machado, E. N. da Silva Júnior* and B. A. Iglesias*

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From the themed collection: Emerging Investigators Series

Journal of Molecular Liquids 387 (2023) 122666
130

Imidazole-based optical sensors as a platform for bisulfite sensing and BSA/HSA interaction study. An experimental and theoretical investigation

 

E. R. S. Paz, V. G. Isoppo, F. S. dos Santos, L. A. Machado, R. P. de Freitas, H. C. Silva Junior, O. A. Chaves, B. A. Iglesias, F. S. Rodembusch* and E. N. da Silva Júnior*

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2022

ACS Sensors 7 (2022) 2865-2919
129

Aryl-phenanthro[9,10-d]imidazole: A versatile scaffold for the design of optical-based sensors

 

G. G. Dias, M. O. Rodrigues, E. R. S. Paz, M. P. Nunes, M. H. Araujo, F S. Rodembusch* and E. N. da Silva Júnior*

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Chemical Communications 58 (2022) 3101-3121
128

Looking deep into C–H functionalization: the synthesis and application of cyclopentadienyl and related metal catalyst

 

G. A. M. Jardim, R. L. de Carvalho, M. P. Nunes, L. A. Machado, L. D. Almeida, K. A. Bahou, J. F. Bower* and E. N. da Silva Júnior*

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Eur. Journal of Organic Chemistry 28 (2022) e202200590
127

Ruthenium(II)-Catalyzed C–H/N–H Alkyne Annulation of Nonsymmetric Imidazoles: Mechanistic Insights by Computation and Photophysical Properties

 

L. A. Machado, E. R. S. Paz, M. H. Araujo, L. D. Almeida, I. A. O. Bozzi, G. G. Dias, C. L. M. Pereira, L. F. Pedrosa, F. Fantuzzi, F. T. Martins, L. A. Cury and E. N. da Silva Júnior*

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J. Chem. Inf. Model. 62 (2022) 6287-6291
126

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

 

A. J. O'Donoghue,* E. N. da Silva Júnior,* R. S. Ferreira* and co-workers
 

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CrystEngComm 24 (2022) 6628-6641
125

Lanthanide(III)-oxamato complexes containing Nd(III) and Ho(III): crystal structures, magnetic properties, and ab initio calculations

R. C. A. Vaz, I. O. Esteves, W. X. C. Oliveira, J. Honorato, F. T. Martins, E. N. da Silva Júnior, D. C. A. Valente, T. M. Cardozo, B. A. C. Horta, D. L. Mariano, W. C. Nunes, E. F. Pedroso and C. L. M. Pereira*

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Journal of Coordination Chemistry 75 (2022) 2384-2399
124

X-ray structure and magnetic properties of a mononuclear complex and a 1D coordination polymer assembled by cobalt(II) ions and a flexible oxamate ligand

J. Parreiras, E. N. Faria, W. X. C. Oliveira, C. B. Pinheiro, W. D. do Pim, E. N. da Silva Júnior, E. F. Pedroso, M. Julve and C. L. M. Pereira*

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Bioorganic Chemistry 124 (2022) 105754
123

Design, Synthesis and in vivo Evaluation of 1,4-dioxo-2-butenyl Aryl Amine Derivatives as a Promising Anti-inflammatory Drug Prototype

I. O. M. F. da Silveira, I. S. B. Moslaves, J. A. I. Muller, R. J. Oliveira, C. R. W. Hortelan, T. T. Okuyama, J. Fernandes, B. Badenoch, L. J. de Campos, L. D. Almeida, J. Mohammad, A. C. F. Martins, A. Beatriz, E. N. da Silva Júnior, M. C. Toffoli-Kadri* and R. S. Gomes*

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Journal of Fluorescence 32 (2022) 1299-1308
122

Multi-conformational luminescence and phosphorescence of few phenazine 1,2,3-triazole molecules

 

P. B. Pinto, K. C. T. da Cruz, E. N. da Silva Júnior and L. A. Cury*

Chemosensors 10 (2022) 19
121

Rational Design and Synthesis of Large Stokes Shift 2,6-Sulphur-Disubstituted BODIPYs for Cell Imaging

A. E. Reese, C. Lochenie, A. Geddis, L. A. Machado, M. C. de Souza, F. F. C. Marques, C. A. de Simone, M. M. Gouvêa, L. F. Pedrosa, E. N. da Silva Júnior* and Marc Vendrell*

Physical Chemistry Chemical Physics 24 (2022) 1183-1190
120

Raman spectra-based structural classificatory analysis of quinoidal and derivative molecular systems

A. P. Pena, R. G. Almeida, J. Campos, H. F. dos Santos, E. N. da Silva Júnior and A. Jorio*

2021

RSC Advances 11 (2021) 40216-40219
119

Introduction to celebrating Latin American talent in chemistry

G. Merino,* M. A. Fernandez-Herrera,* G. J. A. A. Soler-Illia, A. J. G. Zarbin,* V. G. Zuin, E. Chamorro,* L. G. de Oliveira, M. F. Mesko, C. Fraga, I. A. I. Alvarado, J. Dupont, A. F. Nogueira, C. F. O. Graeff, H. O. Pastore, E. N. da Silva Júnior and O. Azzaroni

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This article is part of the themed collection: Celebrating Latin American Talent in Chemistry

The Chemical Record 21 (2021) 2602-2603
118

Special issue: The Brazilian Meeting on Organic Synthesis

A. Fatima and E. N. da Silva Júnior*

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Beilstein Journal of Organic Chemistry 17 (2021) 1849-1938
117

On the application of 3d metals for C–H activation toward bioactive compounds:
The key step for the synthesis of silver bullets

R. L. Carvalho, A. S. de Miranda, M. P. Nunes, R. S. Gomes, G. A. M. Jardim* and E. N. da Silva Júnior*

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Chemistry A European Journal 27 (2021) 12453-12508
116

Decoding directing groups and their pivotal role in C–H activation

K. Murali, L. A. Machado, R. L. Carvalho, L. F. Pedrosa, R. Mukherjee, E. N. da Silva Júnior* and D. Maiti*

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Journal of the Brazilian Chemical Society 32 (2021) 917
115

A Catalysis Guide Focusing on C–H Activation Processes

 

R. L. Carvalho, G. G. Dias, C. L. M. Pereira, P. Ghosh, D. Maiti* and E. N. da Silva Júnior*

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Organic & Biomolecular Chemistry 19 (2021) 525-547
114

Removal and modification of directing groups used in metal-catalyzed C–H functionalization: The magical step of conversion into ‘conventional’ functional groups

 

R. L. Carvalho, R. G. Almeida, M. Karunanidhi, L. A. Machado, L. F. Pedrosa, P. Dolui, D. Maiti* and E. N. da Silva Júnior*

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Advanced Synthesis & Catalysis 363 (2021) 4994-5027
113

Transition-Metal-Catalyzed Selective Alkynylation of C-H Bonds

 

A. S. Sarala, S. Bhowmick, R. L. de Carvalho, S. A. Al-Thabaiti, M. Mokhtar, E. N. da Silva Júnior* and D. Maiti*

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The Journal of Organic Chemistry 86 (2021) 264-278
112

Rhodium(III)-Catalyzed C–H/N–H Alkyne Annulation of nonsymmetric 2-aryl (benz)imidazole derivatives:

Photophysical and Mechanistic Insights

 

G. G. Dias, E. R. S. Paz, J. Y. Kadooca, A. A. Sabino, L. A. Cury, K. Torikai, C. A. de Simone, F. Fantuzzi and E. N. da Silva Júnior*

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RSC Medicinal Chemistry 12 (2021) 1709-1721
111

It takes two to Tango: Synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity

D. J. B. Lima, R. G. Almeida, G. A. M. Jardim, B. P. A. Barbosa, A. C. C. Santos, W. O. Valença, M. R. Scheide, C. C. Gatto, G. G. C. de Carvalho, P. M. S. Costa, C. Pessoa, C. L. M. Pereira, C. Jacob, A. L. Braga* and E. N. da Silva Júnior*

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Liposomes containing 3-arylamino-nor-β-lapachone derivative: development, characterization, and in vitro evaluation of the cytotoxic activity

 

L. V. Rebouças, F. C. E. Oliveira, D. P. Pinheiro, A. C. A. Oliveira, R. G. Almeida, E. N. da Silva Júnior, M. S. Rizzo, M. P. Costa*, G. Zocolo, F. O. S. Ribeiro, D. A. da Silva and C. Pessoa

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Journal of Drug Deliv. Sci. Technology 62 (2021) 102348
110

The Different Facets of Metal-Catalyzed C–H Functionalization Involving Quinone Compounds

 

J. M. Wood, R. L. Carvalho and E. N. da Silva Júnior*

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The Chemical Record 21 (2021) 2604-2637
109

This article also appears in: 18th Brazilian Meeting on Organic Synthesis and Hot Topic: C-H Activation

Ruthenium(II)- and Palladium(II)-Catalyzed Position-Divergent C–H
Oxygenations of Arylated Quinones: Identification of Hydroxylated Quinonoid
Compounds with Potent Trypanocidal Activity

T. B. Gontijo, R. L. Carvalho, L. Dantas-Pereira, R. F. S. Menna-Barreto, T. Rogge, L. Ackermann* and E. N. da Silva Júnior*

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Bioorganic & Medicinal Chemistry 40 (2021) 116164
108
The Chemical Record 21 (2021) 2702-2738
107

Imidazoles and Oxazoles from Lapachones and Phenanthrene-9,10-dione: A Journey through their Synthesis, Biological Studies, and Optical Applications

 

G. G. Dias, E. R. S. Paz, M. P. Nunes, R. L. Carvalho, M. O. Rodrigues, F. S. Rodembusch* and E. N. da Silva Júnior*

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Beilstein Journal of Organic Chemistry 17 (2021) 762-770 
106

Synthesis of β-triazolylenones via metal-free desulfonylative alkylation of N-tosyl-1,2,3-triazoles

 

S. Pati, R. G. Almeida, E. N. da Silva Júnior* and I. N. N. Namboothiri*

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Chemical Biology & Drug Design 98 (2021) 352-362
105

Benzo[a]phenazine derivatives: promising scaffolds to combat resistant Mycobacterium tuberculosis

P. C. B. Halicki, E. N. da Silva Júnior, G. A. M. Jardim, R. G. de Almeida, J. R. M. Vicenti, B. L. Gonçalves, P. E. Almeida da Silva and D. F. Ramos*

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Bioorganic Chemistry 109 (2021) 104662
104

Cathepsin K inhibitors based on 2-amino-1,3,4-oxadiazole derivatives

T. B. Gontijo, P. S. Lima, M. Y. Icimoto, E. C. de Alvarenga, A. K. Carmona, A. A. de Castro, T. C. Ramalho, E. N. da Silva Júnior and R. P. de Freitas*

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CrystEngComm 23 (2021) 1885-1897
103

Ferromagnetic coupling in a dicopper(II) oxamate complex bridged by carboxylate groups

T. T. da Cunha, C. O. C. da Silveira, V. M. M. Barbosa, W. X. C. Oliveira, E. N. da Silva Júnior, F. F. Ferreira, E. F. Pedroso, C. L. M. Pereira*

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From the themed collection: Supramolecular & Polymorphism

Dalton Transactions 50 (2021) 12430-12434
102

Unexpected formation of a dodecanuclear {CoII6CuII6} nanowheel under ambient conditions: magneto-structural correlations

 

W. D. do Pim, I. F. Silva, E. N. da Silva Júnior, H. O. Stumpf, W. X. C. Oliveira, E. F. Pedroso, C. B. Pinheiro, Y. Journaux, F. Fantuzzi, I. Krummenacher, H. Braunschweig, B. Engels, J. Cano, M. Julve and C. L. M. Pereira*

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Current Pharmaceutical Design 27 (2021) 1807-1824
101

Naphthoquinones and derivatives for chemotherapy: perspectives and limitations of their anti-trypanosomatids activities

 

L. Dantas-Pereira, E. F. Cunha-Júnior, V. V. Andrade-Neto, J. F. Bower, G. A. M. Jardim, E. N. da Silva Júnior, E. C. Torres-Santos and R. F. S. Menna-Barreto*

2020

Organic Letters 22 (2020) 265-269
100

Rh-catalyzed [2+2+2] cycloadditions with benzoquinones: de novo access to naphthoquinones for lignan and type II polyketide synthesis

 

J. M. Wood, E. N. da Silva Júnior* and J. F. Bower*

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Part of a Special Issue: Celebrating Chemistry in Latin America

Chemistry A European Journal 26 (2020) 10981-10986
99

Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds

 

E. N. da Silva Júnior,* R. L. de Carvalho, R. G. Almeida, L. G. Rosa, F. Fantuzzi, T. Rogge, P. M. S. Costa, C. Pessoa, C. Jacob and L. Ackermann*

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Part of a Special Issue for the 8th EuChemS Chemistry Congress consisting of contributions from selected speakers and conveners.

To view the complete issue, visit Issue 48.

The Journal of Organic Chemistry 85 (2020) 8825-8843
98

Synthesis of Densely Substituted Sulfonylfurans and Dihydrofurans via Cascade Reactions of α-Functionalized Nitroalkenes with β-Ketosulfones

 

V. Mane, S. Sivanandan, R. Santana, A. Beatriz, E. N. da Silva Júnior* and I. N. N. Namboothiri*

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European Journal of Organic Chemitry (2020) 4474-4486
97

Electrochemical selenation/cyclization of quinones: A rapid, green and efficient access to functionalized trypanocidal and
antitumor compounds

 

A. Kharma, C. Jacob,* I. A. O. Bozzi, G. A. M. Jardim, A. L. Braga, K. Salomão, C. C. Gatto, M. F. S. Silva, C. Pessoa, M. Stangier, L. Ackermann* and E. N. da Silva Júnior*

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Bioorganic & Medicinal Chemistry 28 (2020) 115565
96

Strategies towards potent trypanocidal drugs: application of Rh-catalyzed [2+2+2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi

 

J. M. Wood, N. S. Satam, R. G. Almeida, V. S. Cristani, D. P. Lima, L. D. Pereira, K. Salomão, R. F. S. Menna-Barreto, I. N. N. Namboothiri*, J. F. Bower* and E. N. da Silva Júnior*

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RSC Medicinal Chemistry 11 (2020) 1145-1160
95

Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: Redox and biological implications

 

R. G. Almeida, W. O. Valença, L. G. Rosa, C. A. de Simone, S. L. de Castro, J. M. C. Barbosa, D. P. Pinheiro, C. R. K. Paier, G. G.
C. de Carvalho, C. Pessoa, M. O. F. Goulart, A. Kharma 
and E. N. da Silva Júnior*

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Future Microbiology 15 (2020) 1543-1554
94

Antifungal activity of β-lapachone against Candida spp. resistant to azoles and its aspects upon biofilm formation

C. R. da Silva,* R. de S Campos, J. B. A. Neto, L. S. Sampaio, F. B. S. A. do Nascimento, L. G. A. V. Sá, T. M. Cândido, H. I. F. Magalhães, E. H. G. da Cruz, E. N. da Silva Júnior, M. O. de Moraes, B. C. Cavalcanti, J. Silva, E. S Marinho and H. V. N. Júnior* 

2019

Copper complexes and carbon nanotube-copper ferrite-catalyzed benzenoid A-ring selenation of quinones: An efficient method for the synthesis of trypanocidal agents

 

G. A. M. Jardim, I. A. O. Bozzi, W. X. C. Oliveira, C. Mesquita-Rodrigues, R. F. S. Menna-Barreto, R. A. Kumar, E. Gravel, E. Doris,* A. L. Braga and E. N. da Silva Júnior*

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New Journal of Chemistry 43 (2019) 13751-13763
93
Catalysis Science & Technology 9 (2019) 2742-2748 
92

Carbon nanotube-ruthenium hybrid towards mild oxidation of sulfides to sulfones: Efficient synthesis of diverse sulfonyl compounds

 

R. G. Almeida, R. L. de Carvalho, M. P. Nunes, R. S. Gomes, L. F. Pedrosa, C. A. de Simone, E. Gopi, V. Geertsen, E. Gravel, E. Doris* and E. N. da Silva Júnior*

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Featured in Cover.

Highlighted in Themed collection 2019 Catalysis Science & Technology HOT Articles.

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones

 

E. N. da Silva Júnior,* G. A. M. Jardim, C. Jacob, U. Dhawa, L. Ackermann and S. L. de Castro

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Eur. Journal of Medicinal Chemistry 179 (2019) 863-915
91
Bioorganic & Medicinal Chemistry 27 (2019) 4143-4150
90

Design of hybrid molecules as antimycobacterial compounds: Synthesis of isoniazid-naphthoquinone derivatives and their activity against susceptible and
resistant strains of Mycobacterium tuberculosis

W. J. Reis, I. A. O. Bozzi, M. F. Ribeiro, P. C. B. Halicki, L. A. Ferreira, P. E. A. da Silva, D. F. Ramos,* C. A. de Simone and E. N. da Silva Júnior*

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Bioorganic & Medicinal Chemistry 27 (2019) 3938-3946
89

Natural product-inspired profluorophores for imaging NQO1 activity in tumour
tissues

 

Z. M. Cheng, W. O. Valença, G. G. Dias, J. Scott, N. D. Barth, F. Moliner, G. B. P. Souza, R. J. Mellanby, M. Vendrell* and E. N. da Silva Júnior*

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Featured in the special issue 'Chemical Immunology'

Tetrahedron 75 (2019) 3697-3712 
88

Beyond Copper-Catalyzed Azide-Alkyne 1,3-dipolar Cycloaddition: Synthesis and
mechanism insights

 

R. S. Gomes, G. A. M. Jardim, R. L. de Carvalho, M. H. Araujo and E. N. da Silva Júnior*

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European Journal of Organic Chemistry (2019) 2344-2353 
87

Ruthenium(II)-Catalyzed C–H Alkenylation of Quinones: Diversity-Oriented Strategy for Trypanocidal Compounds

 

G. G. Dias, T. A. do Nascimento, A. K. A. de Almeida, A. C. S. Bombaça, R. F. S. Menna-Barreto, C. Jacob, S. Warratz, E. N. da Silva Júnior* and L. Ackermann*

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Free Radical Biology & Medicine 130 (2019) 408-418
86

Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles.

 

A. C. S. Bombaça, P. G. Viana, A. C. C. Santos, T. L. Silva, A. B. M. Rodrigues, A. C. R. Guimarães, M. O. F. Goulart, E. N. da Silva Júnior and R. F. S. Menna-Barreto* 

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Physical Chemistry Chemical Physics 21 (2019) 3814-3821
85

Dynamics of aggregated states resolved by gated
fluorescence in films of room temperature phosphorescent emitters.

 

P. L. dos Santos, O. J. Silveira, R. Huang, G. A. M. Jardim, M. J. S. Matos, E. N. da Silva Júnior, A. P. Monkman, F. B. Dias and L. A. Cury*

Graphical Abstract PCCP 2019.JPG
Journal of Fluorine Chemistry 220 (2019) 9-15
84

On the synthesis, optical and computational studies of novel BODIPY-based phosphoramidate fluorescent dyes.

 

L. A. Machado, M. C. de Souza, C. M. da Silva, J. Yoneda, L. C. D. de Rezende, F. S. Emery, C. A. de Simone, E. N. da Silva Júnior* and L. F. Pedrosa*

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Physical Chemistry Chemical Physics 21 (2019) 21966-21971
83

Multi-conformational monomer and dimer steady-states in domains of few molecules: the consequences on the phosphorescence emission bands.

G. H. R. Soares, G. A. M. Jardim, E. N. da Silva Júnior and L. A. Cury*

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2018

Chemical Society Reviews 47 (2018) 12-27
82

Quinone-based fluorophores for imaging biological processes

 

G. G. Dias, A. King, F. de Moliner, M. Vendrell* and E. N. da Silva Júnior*

Featured in Front Cover

Highlighted in Themed collection 2018 Emerging Investigators.

Highlighted in Themed collection SBQ-RSC: Celebrating UK-Brazil collaborations.

Highlighted in Themed collection: Probes for in vitro and in vivo fluorescence imaging.

Chemical Science 9 (2018) 6899-6903
81

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

 

T. Rodrigues*, M. Werner, J. Roth, E. H. G. da Cruz, M. C. Marques, P. Akkapeddi, S. A. Lobo, A. Koeberle, F. Corzana, E. N. da Silva Júnior, O. Werz and G. J. L. Bernardes*

WhatsApp Image 2018-08-30 at 02.39.01.jp
Chemical Communications 54 (2018) 7398-7411
80

Weakly-coordinating N-oxide and carbonyl groups for metal catalyzed C–H activation: The case of A-ring functionalization

 

E. N. da Silva Júnior*, G. A. M. Jardim, R. S. Gomes, Y.-F. Liang and L. Ackermann*

Featured in Inside Front Cover.

Chemistry A European Journal 24 (2018) 15227-15235
79

Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon Nanotube-Rhodium Nanohybrid for Naphthols Oxidation: An Efficient Route towards Trypanocidal Quinones

 

R. L. de Carvalho, G. A. M. Jardim, A. C. C. Santos, M. H. Araujo, W. X. C. Oliveira, A. C. S. Bombaça, R. F. S. Menna-Barreto, E. Gopi, E, Gravel, E. Doris* and E. N. da Silva Júnior*

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Featured in Front Cover and Selected as HOT PAPER.

Chemistry A European Journal 24 (2018) 15130
78

Cover Profile: Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon Nanotube-Rhodium Nanohybrid for Naphthols Oxidation: An Efficient Route towards Trypanocidal Quinones

 

R. L. de Carvalho, G. A. M. Jardim, A. C. C. Santos, M. H. Araujo, W. X. C. Oliveira, A. C. S. Bombaça, R. F. S. Menna-Barreto, E. Gopi, E, Gravel, E. Doris* and E. N. da Silva Júnior*

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Chemical Communications 54 (2018) 12840-12843
77

Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents

 

G. G. Dias, T. Rogge, R. Kuniyil, C. Jacob, R. F. S. Menna-Barreto, E. N. da Silva Júnior* and L. Ackermann*

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Eur. Journal of Medicinal Chemistry 151 (2018) 686-704
76

Quinonoid Compounds via Reactions of Lawsone and 2-Aminonaphthoquinone with α-Bromonitroalkenes and Nitroallylic Acetates: Structural Diversity by C-ring Modification and Cytotoxic Evaluation against Cancer Cells

 

T. V. Baiju, R. G. Almeida, S. T. Sivanandan, C. A. de Simone, L. M. Brito, B. C. Cavalcanti, C. Pessoa, I. N. N. Namboothiri* and E. N. da Silva Júnior*

Organic & Biomolecular Chemistry 16 (2018) 1686-1691
75

Direct sequential C-H iodination/organoyl-thiolation for benzenoid A-ring modification of quinonoid deactivated systems: A new protocol for potent trypanocidal quinones

 

G. A. M. Jardim, W. X. C. Oliveira, R. P. de Freitas, R. F. S. Menna-Barreto, T. L. Silva, M. O. F. Goulart and E. N. da Silva Júnior*

Molecules 23 (2018) 83
74

Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions

 

G. A. M. Jardim, E. H. G. da Cruz, W. O. Valença, D. J. B. Lima, B. C. Cavalcanti, C. Pessoa, J. Rafique, A. L. Braga, C. Jacob* and E. N. da Silva Júnior*

Chemical Physics Letters 695 (2018) 176-182
73

Vibronic singlet and triplet steady-state interplay emissions in phenazine-based 1,2,3-triazole films

 

B. B. A. Costa, P. D. C. Souza, R. N. Gontijo, G. A. M. Jardim, R. L. Moreira, E. N. da Silva Júnior and L. A. Cury*

Journal of Fluorine Chemistry 205 (2018) 8-14
72

Multinuclear NMR spectroscopy, photophysical, electrochemical and DNA-binding properties of fluorinated 1,8-naphthyridine-based boron heterocycles

 

H. G. Bonacorso*, T. P. Calheiro, B. A. Iglesias, Carolina H. da Silveira, E. N. da Silva Júnior, A. Ketzer, F. Bublitz, N. Zanatta and M. A. P. Martins

Current Topics in Medicinal Chemistry 18 (2018) 1-7
71

A UBI 31-38 Peptide-coumarin Conjugate: Photophysical Features, Imaging Tracking and Synergism with Amphotericin B Against Cryptococcus

 

S. M. Z. M. D. Ferreira, H. C. Carneiro, R. B. Alves, A. C. S. Batista, E. N. da Silva Júnior, G. G. Dias, J. M. Resende, D. A. Santos, D. L. Oliveira, M. L. Rodrigues and R. P. Freitas*

Frontiers in Chemistry 6 (2018) 339
70

Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplet

F. de Moliner, A. King, G. G. Dias, G. F. de Lima, C A. de Simone, E N. da Silva Júnior* and M. Vendrell*

Microbial Pathogenesis 117 (2018) 32-42
69

Action mechanism of naphthofuranquinones against fluconazole-resistant Candida tropicalis strains evidenced by proteomic analysis: The role of increased endogenous ROS

J. B. A. Neto, C. R. da Silva, R. S. Campos, F. B. S. A. do Nascimento, L. S. Sampaio, A. R. da Silva, M. A. A. Josino, M. O. de Moraes, M. D. P. Lobo, F. B. M. B. Moreno, A. C. O. M. Moreira, R. A. Moreira, T. B. Grangeiro, E. N. da Silva Júnior, H. I. F. Magalhães, D. D. Rocha, B. C. Cavalcanti and H. V. Nobre Júnior*

2017

Physical Chemistry Chemical Physics 19 (2017) 3473-3479
68

Indirect consequences of exciplex states on the phosphorescence lifetime of phenazine-based 1,2,3-triazole luminescent probe

 

B. B. A. Costa, G. A. M. Jardim, P. L. Santos, H. D. R. Calado, A. P. Monkman, F. B. Dias, E. N. da Silva Júnior and L. A. Cury*

Featured in Front Cover.

Highlighted in Themed collection SBQ-RSC: Celebrating UK-Brazil collaborations.

Eur. Journal of Medicinal Chemistry 136 (2017) 406-419
67

Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: Significant Anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones

 

G. A. M. Jardim, T. L. Silva, M. O. F. Goulart, C. A. de Simone, J. M. C. Barbosa, K. Salomão, S. L. de Castro, J. F. Bower and E. N. da Silva Júnior*

ChemistrySelect 2 (2017) 4301-4308
66

Synthesis of Quinone-Based N-Sulfonyl-1,2,3-triazoles: Chemical Reactivity of Rh(II) Azavinyl Carbenes and Antitumor Activity

 

W. O. Valença, T. V. Baiju, F. G. Brito, M. H. Araujo, C. Pessoa, B. C. Cavalcanti, C. A. de Simone, C. Jacob, I. N. N. Namboothiri* and E. N. da Silva Júnior*

New Journal of Chemistry 41 (2017) 3723-3731
65

Cyclometalated ruthenium complexes from naturally occurring quinones: Studies on their photophysical features, computational details and trypanocidal activity

 

C. M. de Souza, R. C. Silva, P. O. Fernandes, J. D. de Souza Filho, H. A. Duarte, M. H. Araujo, C. A. de Simone, S. L. de Castro, R. F. S. Menna-Barreto, C. P. Demicheli and E. N. da Silva Júnior*

Featured in Front Cover.

European Journal of Organic Chemistry (2017) 3763-3773
64

Redox Center Modification of Lapachones Toward the Syntheses of Nitrogenated Heterocycles as Selective Fluorescent Mitochondrial Imaging Probes

 

F. S. dos Santos, G. G. Dias, R. P. de Freitas, Lucas S. Santos, G. F. de Lima, H. A. Duarte, C. A. de Simone, L. M. S. L. Rezende, M. J. X. Vianna, J. R. Correa, B. A. D. Neto and E. N. da Silva Júnior*

Featured in Front Cover.

Bioorganic & Medicinal Chemistry Letters 27 (2017) 4446-4456
63

On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells

 

T. B. Gontijo, R. P. de Freitas, F. S. Emery, L. F. Pedrosa, J. B. Vieira Neto, B. C. Cavalcanti, C. Pessoa, A. King, F. de Moliner, M. Vendrell* and E. N. da Silva Júnior*

Medicinal Chemical Communications 8 (2017) 1993-2002
62

Encapsulation of nor-β-lapachone into poly(D,L)-lactide-co-glycolide (PLGA) microcapsules: full characterization, computational details and cytotoxic activity against human cancer cell lines

 

M. P. Costa, A. C. S. Feitosa, F. C. E. Oliveira, B. C. Cavalcanti, G. G. Dias, E. W. S. Caetano, F. A. M. Sales, V. N. Freire, S. Di Fiore, R. Fischer, L. O. Ladeira, E. N. da Silva Júnior* and C. Pessoa*

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